Glivec 100mg

                                              Glivec 100mg

PRODUCT DETAILS

Active component : Imatinib

Strength : 100mg

Pack : 28 tablets in a container

 DESCRIPTION 

Glivec 100mg is a antineoplastic agents and used by alone regimen or together with other medicines for the treatment of different types of cancer or bone marrow conditions, the main ingredient which is used as imatinib . Glivec 100mg will prevents the development of cancer cells in the body.

DOSAGE

Adult :

PO
Chronic myeloid leukaemia
• Chronic phase:The patients with Chronic phase the drug administrated 400 mg per day, given up to 600 mg/day or 400 mg bid if needed. Glivec 100mg The patients with Blast crisis or accelerated phase administrated 600 mg per day, up to 400 mg bid if required. Acute lymphoblastic leukaemia :Dose of 600 mg per day with induction, consolidation or maintenance therapy ; Monotherapy in relapsed or refractory acute lymphoblastic leukaemia 400 mg per day up to 400 mg bid is administrated for Unresectable, metastatic GI stromal tumours 400 mg/day. starting with100 mg/day in patients w/ith FIP1L1-PDGF-α fusion kinase is given for Hypereosinophilic syndrome Myelodysplastic disease: 400 mg per day. Mastocytosis 400 mg per day. starting with100 mg/day if there is analog eosinophilia. Dermatofibrosarcoma protuberans: 400 mg bid. Glivec 100mg should administer with food through oral route. Imatinib is a protein-tyrosine kinase inhibitor which inhibits the Bcr-Abl tyrosine kinase, the constitutive abnormal tyrosine kinase created by the Philadelphia chromosome abnormality in chronic myeloid leukemia (CML).

PHARMACOLOGY

Glivec 100mg is a group of anti cancer drug which prevents the development of cancer cells and bone marrow condition. Glivec 100mg is also known as tyrosine kinase inhibitor which interferes with the BCR-ABL tyrosine kinase produced by the Philadelphia chromosome abnormality in chronic myeloid (blood cancer) leukaemia(CML). It stops the multiplication and induces suppress in BCR-ABL positive cell lines, thereby leukaemic cells from Philadelphia chromosome positive CML. The drug which also prohibits the receptor kinases for platelet-derived growth factor (PDGF) and stem cell factor (SCF), c-kit, PDGF- and SCF-mediated cellular effects.

BEFORE USE OF GLIVEC - 100MG

CARE TO BE TAKENInform your doctor about previously taking medicine involved in prescription and non prescription, over the counter, vitamins, herbal, nutritional supplements before taking treatment with drug Glivec 100mg Do not consume the aspirin, or products containing aspirin until doctor specifically permit may decrease the effectiveness of this medication. Acetominophen (Tylenol®) may not be recommended. Inform your doctor Before starting this treatment.discuss with health care professional if you are pregnant or chance of to be pregnant Both of the men and women: avoid conceive a child (get pregnant) while on treatment with Glivec 100mg. Impediment way of contraception, such as condoms, are recommended. Inform the consultants , it will be safe to become pregnant or conceive a child after treatment. Avoid breast feed while on medication therapy.

DRUG INTERACTION

Glivec 100mg+ CYP3A4 inhibitor( azole antifungal, macrolide) → increased serum levels
Glivec 100mg + CYP3A4 inducers → reduced serum concentration
Food interaction: with grape fruit Glivec 100mg reduce serum levels.

STORAGE

Glivec 100mg store below 30℃. Place the drug in tight container, protected from sunlight, moisture and freezing Keep out of the children’s Discard the drug after the expiry date. Dispose the unused drug by asking to the Pharmacist.

MISSED DOSE

if a single dose is missed, have the drug probably soon Next dose time reaches then leave the missed dose and continue the regular schedule Please consult with the doctor.

CONTRAINDICATION

Hypersensitivity and lactation contraindicated with Glivec 100mg

SIDE EFFECTS

Some Glivec 100mg side effects of occurring in >30% for patients:
• Low RBC,WBC and platelets: May increased risk for infection, anemia or bleeding; Nausea and vomiting; Swelling of the face, feet, hands (edema) ; Muscle cramps and bone pain; Diarrhea; bleeding problem; Skin rash; Fever.
Less common side effects of Glivec 100mg • Dyspnea; fatigue; athralagia; stomach cramping; heartburn; cold; decreased appetite; constipation, night sweat; weakness; problems in fertility.

Contact Details

Phone :+91-9987711567

Email :applepharmaceutical@gmail.com

Email :info@myapplepharma.com

0091-9987711567