Enzalutamide 40mg Tablets

XTANDI DOSING CONDITIONS AND ADMINISTRATION

Definition:

Xtandi is a hormonal therapy used for advanced prostate cancer treatment, like for 0men who are all affected with prostate carcinoma in metastatic stage. These are majorly indicated for prostate carcinoma, which contains Enzalutamide 40mg, as an active component considered as non steroidal anti-androgen medication. It is involved in association with castration in the therapy of metastatic or long lasting castration resistant prostate cancer. It is a prescribing medicine, the main ingredient which is used as enzalutamide 40mg,only prescribed by medical oncologist.

XTANDI DOSING CONDITIONS AND ADMINISTRATION

The usual prescribed dosage of Xtandi is 160mg as a single dose by taking with or without food. Xtandi is available in the strength of 40mg; four Capsules of Xtandi should be administered at a same time. Enzalutamide 40mgCapsule should not crush, not chew taken with glass of water. Xtandi Dosing adjustment: In patients with ≥ grade III toxicity: Xtandi 40mg therapy should be refuse for one week or the symptoms should be reduced to grade II, then restart with same dose or decreased to 80mg or 120mg Strong CYP2C8 inhibitors: While combining with  Enzalutamide 40mg Capsule, the dosage should be modified by reducing to 80mg as a single dose or avoid this combination. Strong CYP3A4 inducers: Co administration of Xtandi with Strong CYP3A4 inducers, xtandi dosage increased up to 240mg or stop this combination.
MECHANISM

An androgen which is a male hormone is used to develop prostate carcinoma. One of the major hormone secreted by testes and adrenal glands is known as testosterone. Xtandi containing Enzalutamide will interfere with testosterone production, causes tumor cell growth depletion. It interfere with androgen receptor signaling transduction and leads to cancer cell lysis

PRECAUTION:

During the treatment with Enzalutamide 40mg Capsules, patient may suffer with some adverse effects like; Posterior reversible encephalopathy syndrome Seizures In PRES, some neurological disorders occur in patients. The condition can recovered by providing safety measures or discontinue the therapy as soon as possible. PRES is recognized by using MRI In seizures, Before starting the treatment patient must counsel about this adverse reaction and Stop the therapy if possible. Spermatogenesis occurs that may prohibit the male fertility leads to hypo spermatogenesis. In androgen decline the treatment, may have increase exposure of cardiovascular disease like worsening hypertension.
Pregnancy

Pregnancy category of Xtandi Capsule is D Xtandi is contraindicated to pregnancy; it may cause fetal harm even to death.
Lactation

Breast feeding is not suggested, Xtandi is contraindicated in lactation
MISSED DOSE

Xtandi 40mg is a chem. Drug, used in prostate cancer. Xtandi Capsule should not be self medicated, used by the patients only after getting advice from the medical oncologist. If a single dose missed by patient, then must consult with the physician and follow the instructions as per the guidance of medical adviser, the missed dose should be taken within a time or avoid the missed dose and follow the regular schedule.

SIDE EFFECTS:

Some side effects during the therapy using with Enzalutamide 40mg; Back pain, Arthralgia, Muscular weakness, pain, Diarrhea, Hypertension & hot flush, Dizziness, headache, Asthenia conditions, Peripheral edema, Spinal cord compression, paresthesia, Mental impairment, Hypesthesia, Respiratory tract infections, Hematuria, Pollakiuria, Dry skin, Pruritus, Neutropenia, Thrombocytopenia, Increasing bilirubin level, Epistaxis, Infections like sepsis, Fractures, joint injury, and hematomas (Fall associated injuries). Hallucinations.

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