ENZAMIDE - 40MG My Apple Pharma

                      Anti Cancer Drug-Enzamide 40mg


PRODUCT DETAILS:



Brand name : Enzamide 

Active ingredient : Enzalutamide 

Strength :40MG 

Manufactured by : Intas Pharmaceuticals

Package : 28 capsules 

Category : Anti-neoplastic agent

Description:

Enzamide 40mg is a hormonal therapy, for men who are all affected with prostate carcinoma in metastatic stage.Enzamide 40mg tablets are majorly indicated for prostate carcinoma, which contains Enzalutamide, as an active component considered as non steroidal anti-androgen medication. Enzamide 40mg is involved in association with castration in the therapy of metastatic or long lasting castration resistant prostate cancer. Enzamide 40mg is a prescription medicine, the main ingredient which is used as enzalutamide, only prescribed by medical oncologist.

CAPSULES INDICATIONS

The primary usage of Enzamide 40mg tablet is involved in the effective treatment of mCRPC (metastatic castration resistant prostate cancer), taken orally. The effect of anti-androgen viewing by obstruct the testosterone production by inhibiting androgen synthesis, the hormone which is require for cancer cell growth.Enzamide 40mg is majorly used to treat prostate cancer in men.

MECHANISM

The primary usage of Enzamide 40mg tablet is involved in the effective treatment of mCRPC (metastatic castration resistant prostate cancer), taken orally. The effect of anti-androgen viewing by obstruct the testosterone production by inhibiting androgen synthesis, the hormone which is require for cancer cell growth.Enzamide 40mg is majorly used to treat prostate cancer in men.

DOSAGE

The usual prescribed dosage of Enzamide is 160mg as a single dose by taking with or without food.Enzamide is available in the strength of Enzamide 40mg; four tablets ofEnzamide 40mg should be administered at a same time. Enzamide 40mg tablet should not crush, not chew taken with glass of water. Dose adjustment: In patients with ≥ grade III toxicity: Enzamide 40mg therapy should be refuse for one week or the symptoms should be reduced to grade II, then restart with same dose or decreased to 80mg or 120mg Strong CYP2C8 inhibitors: While combining with Enzamide 40mg tablet, the dosage should be modified by reducing to 80mg as a single dose or avoid this combination. Strong CYP3A4 inducers: Co administration of Enzamide 40mg with Strong CYP3A4 inducers, the dosage of Enzamide tablet increased up to 240mg or stop this combination.

WARNING AND PRECAUTIONS

During the treatment with Enzamide 40mg tablets, patient may suffer with some adverse effects like; Posterior reversible encephalopathy syndrome Seizures In PRES, some neurological disorders occur in patients. The condition can recovered by providing safety measures or discontinue the therapy as soon as possible. PRES is recognized by using MRI In seizures, Before starting the treatment patient must counsel about this adverse reaction and Stop the therapy if possible. Spermatogenesis occurs that may prohibit the male fertility leads to hypo spermatogenesis. In androgen decline the treatment, may have increase exposure of cardiovascular disease like worsening hypertension.

Enzamide 40MG INTERACT WITH SOME DRUGS LIKE

Enzamide 40mg tablet combined with CYP2C8 strong inhibitors, causes elevation of plasma concentration time curve of Enzalutamide and its active metabolite. So avoid this combination, otherwise dosage of Enzamide 40mg should be reduced to 80mg. Enzamide with CYP2C8 strong inducers causes variation in plasma exposure of Enzamide 40mg, to minimize this problem to avoid this concomitant. Co administration of Enzamide 40mg tablets with strong inhibitors or CYP3A4, leads to elevate the AUC of Enzalutamide and its metabolite. CYP3A4 strong inducers example like; phenytoin, Phenobarbital, carbamazepine etc combines with Enzamide 40mg tablets causes depletes the plasma exposure of Enzamide 40mg. Moderate CYP3A4 inducers like Bosentan, efavirenz, modafinil, st Johns wort causes decreasing the plasma concentration of Enzamide tablet. Enzamide 40mg tablets are strong CYP3A4 inducers and moderate CYP2C8 & CYP2C19. CYP3A4 strong inducers like Midazolam, CYP2C8 inducers like warfarin, & CYP2C19 inducers like Omeprazole with Enzamide 40mg causes reducing the plasma risk of Midazolam, warfarin & Omeprazole.

SIDE EFFECTS

Enzamide 40mg has Some side effects during the therapy using with Azel; Back pain, Arthralgia, Muscular weakness, pain, Diarrhea, Hypertension & hot flush, Dizziness, headache, Asthenia conditions, Peripheral edema, Spinal cord compression, paresthesia, Mental impairment, Hypesthesia, Respiratory tract infections, Hematuria, Pollakiuria, Dry skin, Pruritus, Neutropenia, Thrombocytopenia, Increasing bilirubin level, Epistaxis, Infections like sepsis, Fractures, joint injury, and hematomas (Fall associated injuries). Hallucinations .

STORAGE

Enzamide 40mg tablet container should be stored at the temperature of 20℃ to 25℃ (68℉ to 77℉). Keep the container in cool and dry place Protect from light.

PREGNANCY

Pregnancy category of Enzamide 40mg tablet is D Enzamide is contraindicated to pregnancy; it may cause fetal harm even to death.


Contact Details:                                                            


Phone :+91-9987711567

Email :applepharmaceutical@gmail.com

Email :info@myapplepharma.com

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