REDITUX - 500MG

               REDITUX - 500MG(ANTI CANCER DRUG)

PRODUCT DETAILS

Brand Name : Reditux

Composition : Rituximab

Strength availability : 500mg

Manufactured by : Dr.Reddy’s

Dosage Form : injection

Packing : 28 tablets

DESCRIPTION:

Reditux 500mg is a anticancer medicine which prevents the growth and spread of cancer cells in the body.
Reditux 500mg will help to prevent the Non- Hodgkins lymphoma or chronic lymphocytic and with combination with another anticancer drugs like methotrexate is used for rheumatoid arthritis symptoms in adult treatment.
Reditux 500mg with steroid regimen combination is given for the treatment of some rare disorders which cause blood vessels and other tissues inflammation in the body.

INDICATION

Reditux 500mg and hyaluronidase human injection are given alone or combination with another drugs to treat certain types of non-Hodgkin's lymphoma and chronic lymphocytic leukemia (cancer start in WBC).
Reditux 500mg injection combination with methotrexate (Otrexup, Rasuvo, Xatmep, others) is also indicated for the treatment rheumatoid arthritis symptoms in adults that have been already treated with a some type of regimen knowns as tumor necrosis factor (TNF) inhibitor. Reditux 500mg is a type in a classification of drugs called monoclonal antibodies.
Reditux 500mg is used to killing cancer cells to treat NHL , CLL, rheumatoid arthritis, granulomatosis with polyangiitis, and microscopic polyangiitis by inhibiting the activity of the immune system parts that can injury the joints, veins, and other blood vessels and cause organs (heart and lungs) damage.

DOSAGE:

Reditux 500mg injection is usually used to administrate only via intravenous infusion not by IV push or bolus.

BEFORE EACH INFUSION THE DRUG IS PREMEDICATE :

First infusion:

Starting treatment rate of 50 mg/hr is administer , in not showing infusion toxicity, rate raised up to 50 mg/hr increments at intervals of 30 min and max of 400 mg/hr.
Successive infusion: initial at rate of 100 mg/hr, in not showing infusion toxicity, rate raised upto 100 mg/hr increments at intervals of 30 min and max of 400 mg/hr.
While combination with CHOP chemotherapy the injection Reditux has not been given. Hence Premedication with corticosteroids must be considered.

LOW GRADE OR FOLLICULAR NON-HODGKINS LYMPHOMA:

The drug Reditux 500mg Dose is 375 mg/m2 as an IV infusion.

Once weeks for 4 or 8 doses administrated for Relapsed treatment
Once weekly for 4 doses administrated for Retreatment for relapsed.
Previously untreated: administer on day 1 of each cycle of chemotherapy, up to 8 doses. In complete or partial response of patient, start with 8 weeks for maintenance following Reditux 500mg in combination with chemotherapy completed then administer 8weeks for 12 doses as a single agent.

ADMINISTRTION :

Take an amount Reditux 500mg injection is administer and diluted to final concentration of 1 mg/ml upto 4 mg/ml as infusion (containing either 0.9% Nacl or 5% dextrose in water). Gently Invert the bag and mix the solution. Discard unused drug left in vial.

OVERDOSAGE:

If over dose occurs seek immediately to the emergency department or poison control help line. please consult the doctor for further clarification.

MECHANISM OF ACTION:

Reditux 500mg is a type of class called as monoclonal antibody. A new type of "targeted" cancer treatment and an integral part of the body's immune system. Naturally the body fused to antibodies in along with an antigen which has entered the body and attack the antigen for destruction by the immune system.
Monoclonal antibiotics which only targeted by an essential cells only, they may cause less toxicity to healthy cell and it is prescribed treatment given only for cancers in which antigens (and the respective antibodies) have been already identified.
Reditux 500mg injection works by linking to the CD20 antigen on normal and malignant B-cells. Hence natural immune security of body are initiated to attach and kill the marked B-cells. Young cells (stem cells) in the bone marrow which will develop into the various cell types and do not have the CD20 antigen. After treatment CD20 antigen allows healthy B-cells to multiply.

PRECAUTIONS

Allgeric condition againstReditux 500mg or any other medication inform your doctor.
Information about past medical history used which include in prescription, non-prescription, vitamins &supplements , nutritional products just inform the doctor.
While using Reditux 500mg do not take any vaccination or immunization without taking advice from doctors.
Avoid use of Reditux 500mg if you are pregnant. It will harm the baby unborn, while using Reditux 500mg use correct birth control to prevent pregnancy and for at least 2 weeks after your treatment ends. Reditux 500mg may affect the ability to have children in women. Inform your doctor if you planning to pregnant.
It is unknown whether Reditux 500mg passes into breast milk , avoid breast-feed while on Reditux 500mg treatment.

DRUG INTERACTION

Reditux 500mg drug interaction has limited data is available at present.
Interation with fludarabine or cyclophosphamide have no effects in pharmacokinetics in CLL patients.
Reditux 500mg combination with methotrexate had no effects in pharmacokinetics.

CONTRAINDICATION

Hypersensitivity or murine proteins.
Active severe infectons in rheumatoid arthritis
Uncontrolled cardiac disease.

SIDE EFFECTS

Common effects: 

fever and chills (flu lik symptoms)

 Less common side effects:

Weakness; nausea ; headache; cough ; dyspnea ; pharyngitis

STORAGE

• Store the drug Reditux 500mg at 2℃ – 3℃

• Keep away from the childerns
• Use the drug Reditux 500mg before expiry date

• Protected from direct sunlight and Do not freeze or shake.
• Discard the unused drug by asking the advice from doctor or pharmacist.

MISSED DOSE

If a dose missed then have the drug soon you remembered, if next dose time reach then leave the missed dose and follow the normal schedule. Do not have 2 dose at a same time. Please consult with doctor for further details.

Contact Details

Phone :+91-9987711567

Email :applepharmaceutical@gmail.com

Email :info@myapplepharma.com