Rituxirel 500mg
RITUXIREL - 500MG(ANTI CANCER DRUG)
PRODUCT DETAILS
Composition : Rituximab
Strength : 500mg
Manufactured by : Reliance Life Sciences Ltd
Dosage form : injection
Pack of 100 mg in 1 vial
DEFINES:
Rituxirel 500mg is an anticancer medicine which prevents the growth and spread of cancer cells in the body.Rituxirel 500mgwill help to prevent the Non- Hodgkin’s lymphoma or chronic lymphocytic and with combination with another anticancer drug like methotrexate is used for rheumatoid arthritis symptoms in adult treatment.
Rituxirel 500mg with steroid regimen combination is given for the treatment of some rare disorders which cause blood vessels and other tissues inflammation in the body.
INDICATIONS
Rituxirel 500mg and hyaluronidase human injection are given alone or combination with other drugs to treat certain types of non-Hodgkin's lymphoma and chronic lymphocytic leukemia (cancer start in WBC).Rituxirel 500mg injection combination with methotrexate (Otrexup, Rasuvo, Xatmep, others) is also indicated for the treatment rheumatoid arthritis symptoms in adults that have been already treated with a some type of regimen knowns as tumor necrosis factor (TNF) inhibitor. Rituxirel 100mg is a type in a classification of drugs called monoclonal antibodies.
Rituxirel 500mg is used to killing cancer cells to treat NHL, CLL, rheumatoid arthritis, granulomatosis with polyangiitis, and microscopic polyangiitis by inhibiting the activity of the immune system parts that can injury the joints, veins, and other blood vessels and cause organs (heart and lungs) damage.
DOSAGE
Rituxirel 500mg injection is usually used to administrate only via intravenous infusion not by IV push or bolus:Before Each Infusion the Drug Is Premediate:
First infusion:
Starting treatment rate of 50 mg/hr. is administer, in not showing infusion toxicity, rate raised up to 50 mg/hr. increments at intervals of 30 min and max of 400 mg/hr.Successive infusion:
initial at rate of 100 mg/hr., in not showing infusion toxicity, rate raised up to 100 mg/hr. increments at intervals of 30 min and max of 400 mg/hr.While combination with CHOP chemotherapy the injection Rituxirel 500mg has not been given. Hence Premedication with corticosteroids must be considered.
Low grade or follicular non-Hodgkin’s lymphoma:
The drug Rituxirel 500mg Dose is 375 mg/m2 as an IV infusion.Once weeks for 4 or 8 doses administrated for Relapsed treatment
Once weekly for 4 doses administrated for Retreatment for relapsed.
ADMINISTRTION :
Take an amount Rituxirel 500mg injection is administer and diluted to final concentration of 1 mg/ml up to 4 mg/ml as infusion (containing either 0.9% Nacl or 5% dextrose in water). Gently Invert the bag and mix the solution. Discard unused drug left in vial.OVERDOSAGE:
If an Rituxirel 500mg overdose occurs seek immediately to the emergency department or poison control help line. Please consult the doctor for further clarification.
MECHANISM OF ACTION
Rituxirel 500mg is a type of class called as monoclonal antibody. A new type of "targeted" cancer treatment and an integral part of the body's immune system. Naturally the body fused to antibodies in along with an antigen which has entered the body and attack the antigen for destruction by the immune system.
Monoclonal antibiotics which only targeted by an essential cell only, they may cause less toxicity to healthy cell and it is prescribed treatment given only for cancers in which antigens (and the respective antibodies) have been already identified.
Rituxirel 500mg injection works by linking to the CD20 antigen on normal and malignant B-cells. Hence natural immune security of body are initiated to attach and kill the marked B-cells. Young cells (stem cells) in the bone marrow which will develop into the various cell types and do not have the CD20 antigen. After treatment CD20 antigen allows healthy B-cells to multiply.
Monoclonal antibiotics which only targeted by an essential cell only, they may cause less toxicity to healthy cell and it is prescribed treatment given only for cancers in which antigens (and the respective antibodies) have been already identified.
Rituxirel 500mg injection works by linking to the CD20 antigen on normal and malignant B-cells. Hence natural immune security of body are initiated to attach and kill the marked B-cells. Young cells (stem cells) in the bone marrow which will develop into the various cell types and do not have the CD20 antigen. After treatment CD20 antigen allows healthy B-cells to multiply.
PRECAUTIONS
Allergic condition against Rituxirel 500mg or any other medication inform your doctor. Information about past medical history used which include in prescription, non-prescription, vitamins &supplements, nutritional products just inform the doctor.
While using Rituxirel 500mg do not take any vaccination or immunization without taking advice from doctors.
Avoid use of Rituxirel 500mg if you are pregnant. It will harm the baby unborn, while using Rituxirel 500mg use correct birth control to prevent pregnancy and for at least 2 weeks after your treatment ends.Rituxirel 500mg may affect the ability to have children in women. Inform your doctor if you planning to pregnant.
It is unknown whether Rituxirel 500mg passes into breast milk, avoid breast-feed while on Rituxirel 500mg treatment.
While using Rituxirel 500mg do not take any vaccination or immunization without taking advice from doctors.
Avoid use of Rituxirel 500mg if you are pregnant. It will harm the baby unborn, while using Rituxirel 500mg use correct birth control to prevent pregnancy and for at least 2 weeks after your treatment ends.Rituxirel 500mg may affect the ability to have children in women. Inform your doctor if you planning to pregnant.
It is unknown whether Rituxirel 500mg passes into breast milk, avoid breast-feed while on Rituxirel 500mg treatment.
STORAGE
Store the drug Rituxirel 500mg at 2℃ – 3℃
Keep away from the childerns
Use the drug Rituxirel 500mg before expiry date
Protected from direct sunlight and Do not freeze or shake.
Discard the unused drug by asking the advice from doctor or pharmacist.
Keep away from the childerns
Use the drug Rituxirel 500mg before expiry date
Protected from direct sunlight and Do not freeze or shake.
Discard the unused drug by asking the advice from doctor or pharmacist.
DRUG INTERACTION
Rituxirel 500mg drug interaction has limited data is available at present.
Interaction with fludarabine or cyclophosphamide have no effects in pharmacokinetics in CLL Rituxirel 500mg combination with methotrexate had no effects in pharmacokinetics.
Interaction with fludarabine or cyclophosphamide have no effects in pharmacokinetics in CLL Rituxirel 500mg combination with methotrexate had no effects in pharmacokinetics.
CONTRAINDICATION
Hypersensitivity or murine proteins.
Active severe infections in rheumatoid arthritis
Uncontrolled cardiac disease.
Active severe infections in rheumatoid arthritis
Uncontrolled cardiac disease.
MISSED DOSE
If a dose missed then have the drug Rituxirel 500mg soon you remembered, if next dose time reach then leave the missed dose and follow the normal schedule.
Do not have 2 doses at a same time. Please consult with doctor for further details.
Do not have 2 doses at a same time. Please consult with doctor for further details.
SIDE EFFECTS
Common effects: fever and chills (flu lik symptoms)
Less common side effects: Weakness; nausea ; headache; cough ; dyspnea ; pharyngitis.
Less common side effects: Weakness; nausea ; headache; cough ; dyspnea ; pharyngitis.
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