ZELGOR - 500MG
ZELGOR - 500MG(ANTI CANCER DRUG)
PRODUCT DETAILS
Trade name : Zelgor
Strength : 500mg
Container : 120 tablets
Manufactured by : Sun Pharmaceuticals Ltd
DESCRIPTION:
Abiraterone is sold under brand name Zelgor 500mgZelgor 500mg is belongs to type of anti-cancer medication that will act by decline the androgen production in the body.
Androgen is a male hormone that can maintained the tumor cell in prostate glands.
This drug is given by co administration with prednisolone, a steroid which reduce the liability of side effects produced by Abiraterone.
DOSAGE
The prescribed dose of Zelgor 500mg is initial as 4 tablets given orally once daily.The drug Zelgor 500mg administrated combination with 5mg prednisolone twice daily in empty stomach.
• Zelgor 500mg Tablets given on an empty stomach.
• Food should not be taken for at least 2 hours before and at least 1 hour after the dose ofZelgor 500mg Tablets is taken.
• Swallowed whole with water.
Zelgor 500mg belongs to anti androgen drugs, that causes to suppress the enzyme 17α-hydroxylase C 17, 20-lyase (CYP17), it is involving in androgen conglomerate.
Reduce the serum testosterone level.
Declined the tumor cell occurred.
Half-life of tablet Zelgor 500mg is 12 ± 5 hours.
• Chew the tablets or Do not crush
MECHANISM OF ACTION
Androgens are balance the production of malignant in prostate.Zelgor 500mg belongs to anti androgen drugs, that causes to suppress the enzyme 17α-hydroxylase C 17, 20-lyase (CYP17), it is involving in androgen conglomerate.
Reduce the serum testosterone level.
Declined the tumor cell occurred.
PHARMACOKINETICS
Absorption:
Time to maximum plasma concentration of Zelgor 500mg tablet takes 12 hours.Distribution:
Maximum bound to the human plasma protein like albumin and alpha-1 acid glycoprotein.Metabolism:
The main two metabolites of Abiraterone in human plasma are Abiraterone sulphate and N-oxide Abiraterone sulphate.Excretion:
The Zelgor 500mg mainly excreted in 88% feces and 5% in urineHalf-life of tablet Zelgor 500mg is 12 ± 5 hours.
SAFETY AND WARNING
Any allergy, serious liver problem or pregnant in patient, Zelgor 500mg therapy should be stopped Avoid taking of other medications, i.e. prescription, over-the-counter, vitamins, herbal remedies, etc. be sure to inform the doctors before the treatment.Do not take Aspirin administrated and products containing aspirin till doctor particularly allow the drug.
DRUG INTERACTION
Interaction of Zelgor 500mg with dextromethorphan will raises the Cmax and AUC of dextromethorphan InteractionZelgor 500mg with strong CYP3A inhibitors or inducers, concomitant use with caution because pharmacokinetics is not evaluated.STORAGE
The drug stored at 15℃-30℃ Keep the drug in dry place.MISSED DOSE
If patient missed the dose ofZelgor 500mg, that missed dose will be skipped and follow the regular dosing schedule.SIDE EFFECTS
Common effects :
Fatigue, Arthralgia, Hypertension, Nausea, edema, Hypokalemia, Diarrhea, vomiting, Cough, headache, Glucocorticoid deficiency, Mineral corticoid deficiency, Hepatotoxicity, Hypertension, Decrease in ka level, Adrenocortical insufficiency Muscular skeletal and Connective tissue disorders: Joint swelling, discomfort, muscle discomfortGeneral Disorder: Edema
Cardiac disorders: Hot flush, hypertension, arrhythmias, chest pain, cardiac failure
GIT disorders: Diarrhea, dyspepsia
Infections and Infestation: UTI
Pulmonary disorder: Cough
Renal: Urinary frequency, nocturia
Injuries: Fractures.
OVERDOSAGE
Zelgor 500mg has no essential antidote, If overdose occurs end treatment with the drug and give general supportive measures such as monitoring arrhythmias and cardiac failure and assess liver function.PREGNANCY
Pregnancy category X: while on therapy withZelgor 500mg tablet if women become pregnant, immediately stop the drug and give counseling to the women. Zelgor 500mg tablet is not recommended
Contact Details
Phone :+91-9987711567Email :applepharmaceutical@gmail.com
Email :info@myapplepharma.com
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